/tropmed/aggregator J.D. MacLean Centre for Tropical & Geographic Medicine - aggregated feeds en https://pubmed.ncbi.nlm.nih.gov/42149962/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260519000555&v=2.20.0 CONCLUSIONS: Post-arboviral symptoms and impaired QOL persisted beyond six months after chikungunya, dengue and Zika. In contrast, post-malaria fatigue syndrome resolved within three months. Mon, 18 May 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/42141885/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260517000658&v=2.20.0 During September 2025-January 2026, 111 travellers (61 female/50 male; median age: 53 years) who acquired chikungunya virus (CHIKV) in Cuba were reported to GeoSentinel. Upon return, 64.2% (70/109) were potentially viraemic. Only 8.2% (9/98) had received pre-travel consultations. The CHIKV was of East-Central-South Africa genotype, closely related to Brazilian strains. International travellers can serve as arboviral outbreak sentinels and, if viraemic, risk introducing CHIKV into areas with... Sat, 16 May 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/42085474/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260506003223&v=2.19.0.post6+133c1fe CONCLUSIONS: HIVST uptake has increased in Africa, with wide variation between countries. HIVST is more likely to engage 25-34-year-olds and men, who have historically been less likely to be aware of their HIV status. Our results can help understand patterns of use and support countries in optimizing their HIV testing services. Tue, 05 May 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/42065736/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260502002903&v=2.19.0.post6+133c1fe Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding... Fri, 01 May 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41871095/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260324022747&v=2.19.0.post6+133c1fe Helminth infections in grazing ruminants are of major concern for animal welfare and cause substantial economic losses, prompting the widespread use of ivermectin (IVM). The emergence of IVM resistance, driven by complex and poorly understood mechanisms, increasingly compromises treatment efficacy. Drug efflux transporters, particularly P-glycoproteins (PGPs), are suspected to contribute to resistance. Yet, the study of their individual and functional role is hindered by their diversity in... Mon, 23 Mar 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41851772/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260320005720&v=2.19.0.post6+133c1fe Several issues that affect prevention and treatment of heartworm infections require more intensive research. The incidence of heartworm infection in the USA is increasing, but the factors that underlie this trend remain incompletely understood. The contributions of climate change, vector range expansion, client compliance and resistance to macrocyclic lactones (ML) are likely interrelated and require investigation. Molecular-level research has not yet identified the causative mechanisms... Thu, 19 Mar 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41820074/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260313014343&v=2.19.0.post6+133c1fe Independent protein-protein interaction networks in kinetoplastid parasites show little overlap, often interpreted as biological divergence. We argue that this pattern largely reflects fragmented sampling. Integrating interactomes from Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani improves functional coverage and interpretability while preserving lineage-specific assemblies, providing a framework for hypothesis generation across species. Thu, 12 Mar 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41803943/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260311002630&v=2.19.0.post6+133c1fe No abstract Tue, 10 Mar 2026 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41786230/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260307014028&v=2.19.0.post6+133c1fe Accurate protein domain annotation is essential for inferring protein function, and databases such as Pfam provide sequence-derived signatures for thousands of domain families. Because protein structure is more evolutionarily conserved than sequence, structure-based searches can detect homologous relationships even at low sequence identity (typically below 30%), where pairwise sequence aligners often lose sensitivity. Here, we leverage AlphaFold-derived structures of Pfam domain instances to... Thu, 05 Mar 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41762163/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260301005853&v=2.19.0.post6+133c1fe MicrobiomeNet (https://microbiomenet.com) is a web-based platform developed to provide functional insights into microbiome signatures using genome-scale metabolic models (GEMs). It currently hosts 12,400 GEMs and around 6 million microbial signatures. Users can start by searching microbes, metabolites, genes, or enzymes, and perform common tasks such as to characterize the metabolic capacity for a given microbe, to explore known microbial associations, as well as to understand potential... Sat, 28 Feb 2026 06:00:00 -0500