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UID:20260523T223943EDT-0206ABW2G4@132.216.98.100
DTSTAMP:20260524T023943Z
DESCRIPTION:SPEAKER:\n\nProfessor Roger Nitsch\n\nFull Professor at the Fac
 ulty of Medicine\, University of Zurich and Director at the Hospital for P
 sychogeriatric Medicine at the Psychiatric University Hospital Zurich.\n\n
  \n\nTITLE:\n\n“Discovery of Aducanumab for the treatment of Alzheimer’s d
 isease”\n\n \n\nALZHEIMER’S DISEASE is characterized by the deposition in 
 brains of amyloid beta plaques and neurofibrillary tangles. Aggregation of
  amyloid beta in brain triggers a slowly progressing sequence of mildly sy
 naptotoxic and neurotoxic activities\, preceding the development of clinic
 al dementia by more than 20 years. Cellular reactions to this chronic toxi
 city include synaptic dysfunction\, tau pathology in neurons with the form
 ation of neurofibrillary tangles and glial cell responses. Collectively\, 
 these pathogenic activities result in chronic neurodegeneration followed b
 y progressive decline of global cognitive functions. As an initiator of th
 is chronic cascade of degenerative activities\, amyloid beta is a genetica
 lly validated target for drug development throughout industry. We have dis
 covered\, and licensed to Biogen\, aducanumab\, the first amyloid beta-rem
 oving antibody receiving accelerated approval by the U.S. FDA. Aducanumab 
 removes brain amyloid beta in a dose- and time-dependent fashion\, the bio
 logical basis for its FDA approval. Aducanumab is derived from human antib
 ody-encoding memory-B cells. Clinical studies designed to confirm initial 
 signs of clinical benefit are ongoing.\n
DTSTART:20220922T193000Z
DTEND:20220922T213000Z
LOCATION:Room 504\, Martin Amphitheater\, McIntyre Medical Building\, CA\, 
 QC\, Montreal\, H3G 1Y6\, 3655 promenade Sir William Osler
SUMMARY:THEODORE L. SOURKES LECTURE IN NEUROPHARMACOLOGY
URL:/pharma/channels/event/theodore-l-sourkes-lecture-
 neuropharmacology-340625
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