Critical Thinking

The Science Behind the Quest for a Non-Peptide Oral Weight Loss Drug

Joe Schwarcz PhD — Thu, 21 May 2026 20:02:24 +0000

Not only does it have a tongue-twisting name, “orforglipron” has a complex molecular structure that made its synthesis very challenging. A massive effort by chemists at the Eli Lilly pharmaceutical company finally resulted in a viable synthesis, but why this massive effort? Because the payoff also promises to be massive! Orforglipron is the first “small molecule” to act as an oral “GLP-1 agonist". Its discovery takes us on a long and winding journey.

Health Monitoring Has Come a Long Way, From Rolled-Up Paper to AI

Joe Schwarcz PhD — Thu, 14 May 2026 21:14:04 +0000

This article was first published in The Montreal Gazette.

Remember Theranos, the company that promised to revolutionize longevity by making health data instantly available from blood collected from a finger prick, allowing for “alerts” to make lifestyle changes?

Alex Clark’s Right-Wing Wellness Podcast Reaches New Lows

Jonathan Jarry M.Sc. — Thu, 14 May 2026 18:43:31 +0000

“Raw milk is better for your teeth than any of these toothpastes you’ll get.”

Why Did LLMs Steal Our Em-Dashes?

Lia Erisson — Fri, 08 May 2026 10:00:00 +0000

Upon ChatGPT's release in 2022, I realized that I wrote like AI. My sentences were long, my writing patterns were predictable, and my use of em-dashes was frequent. Initially, I was not concerned: if models are being trained to write like me, I must be doing a good job, right?

There Is a Hair-Raising Amount of Chemicals Around Us: Are We in Danger?

Joe Schwarcz PhD — Fri, 08 May 2026 10:01:00 +0000

This article was first published in The Montreal Gazette.

Until recently, I had not given any thought to hair extensions, although I was once in a salon where I was amazed at the variety of these products. They were to be found in every possible length, shade and style, made either of real hair or of various synthetic fibres.

Farmers’ Almanacs Are No Better than a Coin Toss

Jonathan Jarry M.Sc. — Thu, 07 May 2026 17:45:51 +0000

A bicentenarian is about to die but I doubt many will notice. Farmers’ Almanac is calling it quits after being in business for 208 years. Its 2026 issue will be its last.

RFK Jr. Has Visions of the Therapeutic Use of Psychedelics Dancing in His Head

Joe Schwarcz PhD — Tue, 05 May 2026 19:54:22 +0000

U.S Health Secretary Robert Kennedy Jr. is sticking his fingers into many pies. One of these contains psychedelics that are either synthetic or natural substances capable of producing changes in mood, cognitive processes and an altered perception of reality often accompanied by hallucinations. Kennedy believes that the U.S. government has hindered research into psychedelics which have been unjustifiably painted with a broad brush as being dangerous.

Why Sunscreen Still Beats Steak

Sophie Tseng Pellar BSc — Fri, 01 May 2026 03:39:26 +0000

This story started like many modern tales of data distortion do, where the science isn’t denied outright, but bent just enough to fit a more convenient (and lucrative) narrative. Let me regretfully introduce you to Kashif Khan—a self-proclaimed “Truth Teller and Longevity Innovator”. It should be noted, however, that for a man who has built his career around dispensing health advice, his résumé appears to be entirely free of anything resembling a medical or scientific qualification. No degree, no training, not even a suspiciously vague wellness certification.

In my Inbox — Spinach, Blueberries, Hold the Baloney

Joe Schwarcz PhD — Fri, 01 May 2026 03:25:28 +0000

This article was first published in The Montreal Gazette.

Let me tell you about my morning regimen.

The Hallmarks of Pseudoscience

Jonathan Jarry M.Sc. — Fri, 01 May 2026 02:59:11 +0000

I’ve been investigating pseudoscientific claims for 13 years now. The word “pseudoscience” means “fake science,” something that superficially looks like science—and is often sold as such—but that isn’t. It attempts to imitate it without reaching equivalence.

Just How Much Should You Worry About Eating That Burnt Toast?

Joe Schwarcz PhD — Fri, 24 Apr 2026 21:25:27 +0000

I was tempted to say, “why don’t you buy the book,” but that sounded a bit too self-serving. So, let me dig into the science which centers around a small molecule called acrylamide. The International Agency for Research on Cancer (IARC) has placed acrylamide in its Category 2B reserved for “substances that are possibly carcinogenic to humans.” That raises eyebrows when we learn that this possible carcinogen can be found in many common foods. Think French fries, cereals, potato chips, toast and yikes…coffee.

“Talk to Me in French, Talk to Me in Spanish”: Exploring the Benefits of Bilingualism

Eva Kellner B.A.Sc. — Fri, 24 Apr 2026 10:00:00 +0000

Despite not being bilingual myself, from growing up in New York City, to my undergraduate days spent in Montreal, to now calling Prague home, I have always been immersed in bi- and multilingual worlds. (Bilingualism being the ability to speak/use two languages, and multilingualism is the ability to speak/use more than two.) I even had the privilege to grow up in a home with a bilingual father yet was never taught his native language, Czech. I always resented this, as I dwelled on the fact that I didn’t have the opportunity to learn Czech the “easy way.”

Can You Warm Up Your Body with Your Mind?

Jonathan Jarry M.Sc. — Thu, 23 Apr 2026 18:10:34 +0000

If you concentrate hard, can you raise the temperature of your little finger? The human body has a thermostat of sorts, a way of regulating its temperature and ensuring its heart keeps beating even when we’re freezing; but can we adjust it with the power of our mind?

The Leggings That Promise to Fix Your Knees

Sophie Tseng Pellar BSc — Thu, 16 Apr 2026 20:28:39 +0000

Back when I was a varsity athlete (before I became old and washed up), I spent my final season dealing with a particularly stubborn ankle injury. As it turns out, sprinting down a runway and launching yourself into a sandpit while transferring large amounts of force through a compromised joint is not exactly a recipe for orthopedic success. Who would’ve guessed.

Scary Videos Claim That You Are Risking Your Health by Reheating Leftovers. Are You Really?

Joe Schwarcz PhD — Thu, 16 Apr 2026 20:07:20 +0000

Bacteria are everywhere. Most are harmless but some are “pathogenic,” meaning they can cause disease. They can carry out their mischief in two ways. One possibility is that they can survive passage through the stomach, start multiplying in the intestine, and damage intestinal cells by invading them. This causes the body’s immune system to spring into action causing inflammation with its symptoms of pain and fever.