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UID:20260523T062746EDT-84066opGZ1@132.216.98.100
DTSTAMP:20260523T102746Z
DESCRIPTION:Abstract\n\nProstate cancer is a significant public health conc
 ern in the United States and globally\, causing a substantial number of ma
 le deaths each year\, ranking second in terms of cancer−related mortality.
  Focal therapy\, an emerging approach in prostate cancer treatment\, aims 
 to ablate malignant tissues while preserving the neighboring healthy tissu
 es precisely. Photothermal therapy holds promise as a focal treatment opti
 on for prostate cancer\, overcoming the limitations of conventional therap
 ies through nanoparticle−based approaches. Despite recent advancements in 
 the development of diverse photothermal agents\, further progress is urgen
 tly required in photothermal therapy. These photothermal transducers shoul
 d possess the ability to absorb near−infrared (NIR) light and convert it i
 nto heat\, enabling localized hyperthermia and the subsequent destruction 
 of cancer cells. It is crucial for these transducers to absorb light withi
 n the NIR region\, which corresponds to the biological window\, and to enh
 ance heat generation\, specifically at the cellular level.\n\nMultiwalled 
 carbon nanotubes (MWCNTs) have attracted significant attention in photothe
 rmal therapy owing to their exceptional optical and surface properties. Ho
 wever\, their limited absorption within the biologically relevant 800 nm w
 indow requires exploration of methods to enhance their absorption and impr
 ove the light−to−heat conversion. Here\, we propose covalently attaching p
 lasmonic gold nanorods (GNRs) to the surface of MWCNTs\, which exhibit loc
 alized surface plasmon resonance within the therapeutic window. This thesi
 s delves into exploring the potential clinical applications of MWCNTs−GNRs
  within the first near-infrared window (650 − 950 nm).\n\nOur investigatio
 n encompasses the optical and thermal characterization of our plasmonic hy
 brid nanostructure\, analyzing their light−to−conversion efficiency\, temp
 erature profiles\, and potential use as temperature probes using Raman spe
 ctroscopy. Through numerical and experimental analyses of the optical and 
 thermal properties of the decorated carbon nanotubes\, we present our find
 ings from near-infrared photothermal measurements and quantitative analysi
 s of the hybrid carbon nanostructure using a laser wavelength of 808 nm. F
 urthermore\, we evaluated the in vitro performance of MWCNTs−GNRs as photo
 thermal agents\, which resulted in the efficient thermal ablation of cance
 r cells\, surpassing the capabilities of current plasmonic nanostructures.
 \n\nUsing prostate cancer cell lines\, we demonstrated the effective use o
 f MWCNTs−GNRs as nanoprobe thermometers for photothermal therapy by measur
 ing its anti−Stokes and Stokes signals at different laser powers. Our resu
 lts revealed that gold-decorated MWCNTs effectively heated cancer cells an
 d enabled non-invasive temperature monitoring. The proposed hybrid nanopar
 ticle addresses the current constraints of photothermal therapy and serves
  as a foundation for advancing a new generation of photothermal therapy ag
 ents. This will pave the way for the development of enhanced and innovativ
 e cancer treatment methods.\n
DTSTART:20240521T153000Z
DTEND:20240521T173000Z
LOCATION:Room 603\, McConnell Engineering Building\, CA\, QC\, Montreal\, H
 3A 0E9\, 3480 rue University
SUMMARY:PhD defence of Fatma Oudjedi – Exploring the therapeutic potential 
 of plasmonic hybrid multiwalled carbon nanotubes in cancer treatment and b
 eyond
URL:/ece/channels/event/phd-defence-fatma-oudjedi-expl
 oring-therapeutic-potential-plasmonic-hybrid-multiwalled-carbon-357362
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